Most accounts of responsibility begin from either of two prominent points of departure: the idea that an agent must have some characterological or expressive connection to the action, or alternately, the idea that an agent must be in some sense responsive to reasons.Here, I will argue that the relation between these two approaches to moral responsi
Abstract The COVID-19 pandemic has pushed healthcare systems globally to a breaking point.The urgent need for effective and affordable COVID-19 treatments calls for repurposing combinations of approved drugs.The challenge is to identify which combinations are likely to be most effective and at what stages of Hats the disease.Here, we present the fi
We have undertaken a detailed analysis of the biotransformation of five of the most therapeutically important benzimidazole anthelmintics - albendazole (ABZ), mebendazole (MBZ), thiabendazole (TBZ), oxfendazole (OxBZ) and fenbendazole (FBZ) - in Caenorhabditis elegans and the ruminant parasite Haemonchus contortus.Drug metabolites were detected by
Multi-temporal SAR interferometry (MTInSAR), by providing both mean displacement maps and displacement time series over coherent objects on the Earth’s surface, allows analyzing wide areas, identifying ground displacements, and studying the phenomenon evolution at a long time scale.This technique has also been proven to be very useful for detecti
The routes of early Deck Spindles railways around the world were generally inefficient because of the incorrect assumption that long distance travel between major cities would dominate.Modern planners rely on methods such as the “gravity models of spatial interaction,” which show quantitatively the importance of accommodating travel demands bet